Reactome | p-STAT1 dimer translocates from the cytosol to the nucleoplasm

p-STAT1 dimer translocates from the cytosol to the nucleoplasm

Stable Identifier

R-HSA-8987218

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

Synonyms

p-STAT1 dimer translocates from the cytosol to the nucleoplasm after IL24 stimulus, stat1 translocates from the cytosol to the nucleoplasm

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p-STAT1 dimer translocates from the cytosol to the nucleoplasm

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Signal transducer and activator of transcription 1 alpha/beta (STAT1) dimer translocates from the cytosol to the nucleus after Interleukin-24 stimulus (IL24) (in BHK cells bearing IL 20RA/IL 20RB) (Parrish Novak et al. 2007). This is a black box event because the mechanism by which this event occurs (diffusion, transport) is unknown (Darnell 1997).

Literature References

PubMed ID	Title	Journal	Year
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA	J Biol Chem	2002