Phosphorylated Signal transducer and activator of transcription 3 (STAT3) is believed to dimerize after it dissociates from the Interleukin-24 (IL24) receptor complex. This is a black box event because dimerization is inferred from STAT3 dimerization in response to interleukin-10 (Niemand et al. 2003) and the observed translocation of STAT3 to the nucleus in response to IL24 (Parrish-Novak et al. 2002). In several other cytokine signalling cascades a phosphorylated dimer is necessary for binding to DNA and gene transcription (Park et al. 2000).
Madden, K, Chandrasekher, YA, Yao, L, Brandt, C, Foster, DC, Jelinek, L, Brender, T, McKernan, PA, Jaspers, S, West, J, Jones, C, Parrish-Novak, J, Xu, W
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