p-STAT3 dimerizes

Stable Identifier
R-HSA-8987214
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
p-STAT3 dimerizes after IL24 stimulus
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p-STAT3 dimerizes
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Phosphorylated Signal transducer and activator of transcription 3 (STAT3) is believed to dimerize after it dissociates from the Interleukin-24 (IL24) receptor complex.
This is a black box event because dimerization is inferred from STAT3 dimerization in response to interleukin-10 (Niemand et al. 2003) and the observed translocation of STAT3 to the nucleus in response to IL24 (Parrish-Novak et al. 2002). In several other cytokine signalling cascades a phosphorylated dimer is necessary for binding to DNA and gene transcription (Park et al. 2000).

Literature References
PubMed ID Title Journal Year
12351624 Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions

Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA

J Biol Chem 2002
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Authored
Duenas, C  (2017-03-16)
Reviewed
Datta, SK  (2017-11-15)
Created
Duenas, C  (2017-05-05)