Reactome | p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3

p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3

Stable Identifier

R-HSA-8987161

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

p-STAT3 dissociates from IL24:IL22RA1:p-JAK1:IL20RB:p-STAT3 activated receptor complex, p-stat3 dissociates from il22r il20rb receptor activated complex

ReviewStatus

5/5

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p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3

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Phosphorylated Signal transducer and activator of transcription 3 (STAT3) dissociates from Interleukin-24 (IL24) activated receptor complex. This activated receptor complex is formed by IL24 ligand, Interleukin-22 receptor subunit alpha-1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish-Novak et al. 2002). This is a black box event since there is no direct evidence of this dissociation but there is evidence dissociation occurs before translocation in other interleukin signaling cascades.

Literature References

PubMed ID	Title	Journal	Year
11706020	Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 Wang, M, Tan, Z, Zhang, R, Kotenko, SV, Liang, P	J. Biol. Chem.	2002
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA	J Biol Chem	2002