p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3

Stable Identifier
R-HSA-8987161
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
p-STAT3 dissociates from IL24:IL22RA1:p-JAK1:IL20RB:p-STAT3 activated receptor complex, p-stat3 dissociates from il22r il20rb receptor activated complex
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Phosphorylated Signal transducer and activator of transcription 3 (STAT3) dissociates from Interleukin-24 (IL24) activated receptor complex. This activated receptor complex is formed by IL24 ligand, Interleukin-22 receptor subunit alpha-1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish-Novak et al. 2002). This is a black box event since there is no direct evidence of this dissociation but there is evidence dissociation occurs before translocation in other interleukin signaling cascades.

Literature References
PubMed ID Title Journal Year
12351624 Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions

Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA

J Biol Chem 2002
11706020 Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2

Wang, M, Tan, Z, Zhang, R, Kotenko, SV, Liang, P

J. Biol. Chem. 2002
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