Reactome | p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3

p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3

Stable Identifier

R-HSA-8987156

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3

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Phosphorylated Signal transducer and activator of transcription 5A or 5B (STAT5) dissociates from the Interleukin-20 (IL20) receptor complex (Tristaris et al. 2007). This is a black box event because dissociation is inferred from the signalling events of other Interleukins where phosphorylated STATs translocate to the nucleus, as with Interleukin-3 (Hirose et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
17878297	IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs Tritsaris, K, Myren, M, Ditlev, SB, Hübschmann, MV, van der Blom, I, Hansen, AJ, Olsen, UB, Cao, R, Zhang, J, Jia, T, Wahlberg, E, Dissing, S, Cao, Y	Proc. Natl. Acad. Sci. U.S.A.	2007