Reactome | IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3

IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3

Stable Identifier

R-HSA-8987150

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

STAT3 is phosphorylated by IL24:p-IL20RA:p-JAK1:IL20RB:STAT3 activated receptor complex, STAT3 is phosphorylated in IL24:IL24 receptor complex

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Signal transducer and activator of transcription 1 alpha/beta (STAT1) and Signal transducer and activator of transcription 3 (STAT3) are believed to be phosphorylated after binding the Interleukin-24 (IL24) receptor complex (Parrish Novak et al. 1998, Andoh et al. 2009, Wang et al. 2002). This complex consists of IL24 ligand, phosphorylated Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-20 receptor subunit beta (IL20RB) and STAT1 or STAT3 .
This is a black box event because STAT binding is inferred to precede STAT phosphorylation.

Literature References

PubMed ID	Title	Journal	Year
19535621	Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease Andoh, A, Shioya, M, Nishida, A, Bamba, S, Tsujikawa, T, Kim-Mitsuyama, S, Fujiyama, Y	J. Immunol.	2009
18941194	IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression Sainz-Perez, A, Gary-Gouy, H, Gaudin, F, Maarof, G, Marfaing-Koka, A, de Revel, T, Dalloul, A	J. Immunol.	2008