Reactome | IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3

IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3

Stable Identifier

R-HSA-8987150

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

STAT3 is phosphorylated by IL24:p-IL20RA:p-JAK1:IL20RB:STAT3 activated receptor complex, STAT3 is phosphorylated in IL24:IL24 receptor complex

ReviewStatus

5/5

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IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3

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Signal transducer and activator of transcription 1 alpha/beta (STAT1) and Signal transducer and activator of transcription 3 (STAT3) are believed to be phosphorylated after binding the Interleukin-24 (IL24) receptor complex (Parrish Novak et al. 1998, Andoh et al. 2009, Wang et al. 2002). This complex consists of IL24 ligand, phosphorylated Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-20 receptor subunit beta (IL20RB) and STAT1 or STAT3 .
This is a black box event because STAT binding is inferred to precede STAT phosphorylation.

Literature References

PubMed ID	Title	Journal	Year
19535621	Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease Bamba, S, Kim-Mitsuyama, S, Andoh, A, Fujiyama, Y, Nishida, A, Tsujikawa, T, Shioya, M	J. Immunol.	2009
18941194	IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression Marfaing-Koka, A, de Revel, T, Sainz-Perez, A, Gaudin, F, Maarof, G, Gary-Gouy, H, Dalloul, A	J. Immunol.	2008