Reactome | IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3

IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3

Stable Identifier

R-HSA-8987141

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3

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Signal transducer and activator of transcription 5A and 5B (STAT5A, STAT5B) is phosphorylated after binding the Interleukin-20 (IL20) receptor complex, which consist of IL20, Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-20 receptor subunit beta (IL20RB), phosphorylated Tyrosine-protein kinase JAK2 (JAK2), Tyrosine-protein kinase JAK3 (JAK3) and STAT5. After IL20 stimulation STAT5 is phosphorylated at Tyr-694 (Tritsaris et al. 2007). It is not clear which kinase subunit of the receptor complex is responsible for STAT5 phosphorylation.

Literature References

PubMed ID	Title	Journal	Year
17878297	IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs Jia, T, Myren, M, Olsen, UB, Hansen, AJ, van der Blom, I, Ditlev, SB, Dissing, S, Cao, Y, Zhang, J, Hübschmann, MV, Tritsaris, K, Cao, R, Wahlberg, E	Proc. Natl. Acad. Sci. U.S.A.	2007