JAK1 binds IFNLR1

Stable Identifier
R-HSA-8987120
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
JAK1 binds IL28RA
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JAK1 binds IFNLR1
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Tyrosine protein kinase JAK1 (JAK1) binds Interferon lambda receptor 1 (IFNLR1).
The Box1 of IFNLR1 binds to the F2 subdomain of the JAK1 FERM, in a cleft formed by helices F2 alpha2, F2 alpha3, and F2 alpha4 (Ferrao et al. 2017).

Literature References
PubMed ID Title Journal Year
28458652 The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions

Lupardus, PJ, Ferrao, R

Front Endocrinol (Lausanne) 2017
Participants
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Orthologous Events
JAK1 binds IFNLR1 (Bos taurus)
JAK1 binds IFNLR1 (Canis familiaris)
JAK1 binds IFNLR1 (Danio rerio)
JAK1 binds IFNLR1 (Gallus gallus)
JAK1 binds IFNLR1 (Mus musculus)
JAK1 binds IFNLR1 (Rattus norvegicus)
JAK1 binds IFNLR1 (Sus scrofa)
JAK1 binds IFNLR1 (Xenopus tropicalis)
Authored
Duenas, C  (2017-03-16)
Reviewed
Datta, SK  (2017-11-15)
Created
Duenas, C  (2017-05-05)
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