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p-Y343-Y517-IFNLR1 [plasma membrane]
Stable Identifier
R-HSA-8987118
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1, p-Y-STAT2, p-STAT3 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1 [plasma membrane] (Homo sapiens)
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1 [plasma membrane] (Homo sapiens)
p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1, p-Y-STAT2, p-STAT3 [plasma membrane] (Homo sapiens)
IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y343-Y517-IFNLR1 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15166220
Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling (Dumoutier et al. ).
Michiels, T
,
Dumoutier, L
,
Renauld, JC
,
Sommereyns, C
,
Kotenko, SV
,
Tounsi, A
J. Biol. Chem.
2004
External Reference Information
External Reference
UniProt:Q8IU57 IFNLR1
Gene Names
IFNLR1, IL28RA, LICR2
Chain
signal peptide:1-20, chain:21-520
Reference Genes
BioGPS Gene:163702 IFNLR1
COSMIC (genes):IFNLR1 IFNLR1
CTD Gene:163702 IFNLR1
dbSNP Gene:163702 IFNLR1
ENSEMBL:ENSG00000185436 IFNLR1
HGNC:18584 IFNLR1
KEGG Gene (Homo sapiens):163702 IFNLR1
Monarch:163702 IFNLR1
NCBI Gene:163702 IFNLR1
OMIM:607404 IFNLR1
UCSC:Q8IU57 IFNLR1
Reference Transcript
RefSeq:NM_173065.2 IFNLR1
RefSeq:NM_173064.2 IFNLR1
RefSeq:NM_170743.3 IFNLR1
Other Identifiers
0006520180
11730080_x_at
1555499_a_at
163702
16683551
2401775
2401776
2401777
2401778
2401779
2401780
2401781
2401782
2401783
2401784
2401785
2401786
2401787
2401788
2401789
2401790
2401796
2401797
2401798
244261_at
75510_at
7913776
A_23_P74112
A_24_P19677
A_33_P3268612
GE563816
GO:0002376
GO:0002385
GO:0003674
GO:0004896
GO:0005515
GO:0005575
GO:0005886
GO:0006091
GO:0006950
GO:0007165
GO:0008150
GO:0008283
GO:0008285
GO:0016020
GO:0016021
GO:0019221
GO:0032002
GO:0032991
GO:0034342
GO:0050691
GO:0051607
GO:1901857
HMNXSV003039289
Hs.105866.0.A1_3p_at
Hs2.386334.2.S1_3p_a_at
ILMN_1680805
ILMN_2405324
PH_hs_0018781
TC01002359.hg
Participates
as a component of
p-Y343-Y517-IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
IFNLR1 [plasma membrane]
Inferred To
phospho-IFNLR1 [plasma membrane]
(Bos taurus)
phospho-IFNLR1 [plasma membrane]
(Canis familiaris)
phospho-IFNLR1 [plasma membrane]
(Gallus gallus)
phospho-IFNLR1 [plasma membrane]
(Sus scrofa)
phospho-ifnlr1 [plasma membrane]
(Danio rerio)
phospho-ifnlr1 [plasma membrane]
(Xenopus tropicalis)
phospho-Ifnlr1 [plasma membrane]
(Mus musculus)
phospho-Ifnlr1 [plasma membrane]
(Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 343
Coordinate
343
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 517
Coordinate
517
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_775087.1
,
NP_775088.1
,
NP_734464.1
Guide to Pharmacology - Targets
1733
OpenTargets
ENSG00000185436
GeneCards
Q8IU57
HPA
ENSG00000185436-IFNLR1
Ensembl
ENSP00000363542
,
ENSP00000328994
,
ENST00000374418
,
ENSG00000185436
,
ENST00000374421
,
ENST00000327535
,
ENST00000327575
,
ENSP00000363539
,
ENSP00000327824
PRO
Q8IU57
Pharos - Targets
Q8IU57
GlyGen
Q8IU57
Orphanet
29102
PDB
5T5W
,
5IXI
,
3OG6
,
3OG4
,
5L04
,
5IXD
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6PL45-2 BRICD5
0.556
3
UniProt:P09466 PAEP
0.556
3
UniProt:Q86W74-2 ANKRD46
0.556
3
UniProt:Q4LDR2 CTXN3
0.556
3
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