Reactome | IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3

IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3

Stable Identifier

R-HSA-8987104

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

STAT5 binds to IL20:IL20RA:JAK1:IL20RB:p-JAK2,p-JAK3 activated receptor complex, STAT5 binds to Activated IL20 IL20 Receptor JAK2 complex

ReviewStatus

5/5

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IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3

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Signal transducer and activator of transcription 3 (STAT3)and STAT5 are believed to bind the receptor complex following the phosphorylation of JAK2 and JAK3 within the IL20:IL20RA receptor complex, because Interleukin-20 (IL20) stimulation leads to STAT3 nuclear translocation (Blumberg et al. 2001, Parrish-Novak et a. 2002)). Phosphorylation of STAT5 at Tyr-694 has been observed in response to IL20 but it is not clear which IL20 receptor was involved (Tritsaris et al. 2007). This is a black box event because there is no direct evidence of STAT3 or STAT5 binding, which is inferred to be a prerequisite for STAT phosphorylation in response to IL20.

Literature References

PubMed ID	Title	Journal	Year
11163236	Interleukin 20: discovery, receptor identification, and role in epidermal function Sexson, S, Parrish-Novak, J, Dale, BA, Xu, WF, Eagan, M, Yao, L, Madden, K, Carollo, S, Prunkard, D, Kuechle, MK, Whitmore, TE, Kelly, JD, Hammond, A, Blumberg, H, Foster, D, Sprecher, C, Chandrasekher, YA, Jelinek, L, Brender, T, Grossmann, A, Conklin, D, Haugen, H, West, J, Haldeman, BA, Waggie, K, Maurer, MF	Cell	2001
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Madden, K, Chandrasekher, YA, Yao, L, Brandt, C, Foster, DC, Jelinek, L, Brender, T, McKernan, PA, Jaspers, S, West, J, Jones, C, Parrish-Novak, J, Xu, W	J Biol Chem	2002