IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3

Stable Identifier
R-HSA-8987097
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
STAT3 binds IL24:p-IL20RA:p-JAK1:IL20RB activated receptor complex, STAT3 binds p-IL20RA from IL24:IL24 receptor complex
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Signal transducer and activator of transcription 1 alpha/beta (STAT1) and Signal transducer and activator of transcription 3 (STAT3) are believed to bind the Interleukin-24 (IL24) receptor complex (Wang et al. 2002, Andoh et al. 2009, Parrish-Novak et al. 1998, Li et al. 2013). This is a black box event because STAT3 binding is inferred from other interleukin receptor ligand interactions where STAT3 activation is followed by a transient interaction with the receptor complex e.g.Interleukin-10 receptor (Weber-Nordt et al. 1996).
Literature References
PubMed ID Title Journal Year
19535621 Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease

Bamba, S, Kim-Mitsuyama, S, Andoh, A, Fujiyama, Y, Nishida, A, Tsujikawa, T, Shioya, M

J. Immunol. 2009
18941194 IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression

Marfaing-Koka, A, de Revel, T, Sainz-Perez, A, Gaudin, F, Maarof, G, Gary-Gouy, H, Dalloul, A

J. Immunol. 2008
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!