IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3

Stable Identifier
Reaction [uncertain]
Homo sapiens
stat3 is phosphorylated by il22r il20rb receptor activated complex
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Signal transducer and activator of transcription 3 (STAT3) is phosphorylated after binding to Interleukin-24 (IL24) activated receptor complex. This activated receptor complex is formed by IL24 ligand, Interleukin-22 receptor subunit alpha-1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish-Novak et al. 2002, Wang et al. 2002, Dumoutier et al. 2001).
This is a black box event since the identity of the phosphorylated residues in STAT3 is unknown.
Literature References
PubMed ID Title Journal Year
11706020 Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2

Liang, P, Zhang, R, Wang, M, Tan, Z, Kotenko, SV

J. Biol. Chem. 2002
11564763 Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types

Renauld, JC, Kotenko, SV, Leemans, C, Dumoutier, L, Lejeune, D

J Immunol 2001
12351624 Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions

Madden, K, Chandrasekher, YA, Yao, L, Brandt, C, Foster, DC, Jelinek, L, Brender, T, McKernan, PA, Jaspers, S, West, J, Jones, C, Parrish-Novak, J, Xu, W

J Biol Chem 2002
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of IL24:IL22RA1:p-JAK1:IL20RB:STAT3 [plasma membrane]

Orthologous Events
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