IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3

Stable Identifier
R-HSA-8987096
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
stat3 is phosphorylated by il22r il20rb receptor activated complex
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Signal transducer and activator of transcription 3 (STAT3) is phosphorylated after binding to Interleukin-24 (IL24) activated receptor complex. This activated receptor complex is formed by IL24 ligand, Interleukin-22 receptor subunit alpha-1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish-Novak et al. 2002, Wang et al. 2002, Dumoutier et al. 2001).
This is a black box event since the identity of the phosphorylated residues in STAT3 is unknown.

Literature References
PubMed ID Title Journal Year
11564763 Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types

Dumoutier, L, Leemans, C, Lejeune, D, Kotenko, SV, Renauld, JC

J Immunol 2001
11706020 Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2

Wang, M, Tan, Z, Zhang, R, Kotenko, SV, Liang, P

J. Biol. Chem. 2002
12351624 Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions

Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL24:IL22RA1:p-JAK1:IL20RB:STAT3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created