Reactome | IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3

IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3

Stable Identifier

R-HSA-8987080

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

STAT1 binds IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 activated receptor complex, STAT1 binds IL10RB from phosphorylated IL26 receptor

ReviewStatus

5/5

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IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3

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Signal transducer and activator of transcription 1 alpha/beta (STAT1) or Signal transducer and activator of transcription 3 (STAT3) are believed to bind the Interleukin-26 (IL26) receptor complex, which consists of IL26, Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2), Interleukin-20 receptor subunit alpha (IL20RA) and phosphorylated Tyrosine-protein kinase JAK1 (JAK1) (Sheikh et al. 2004).
This is a black box event since there is no direct evidence that STAT1 or STAT3 bind to the receptor complex before being phosphorylated but this can be inferred from the signaling mechanism of other related interleukin receptors such as IL10 (Weber-Nordt et al. 1996, Braum et al. 2013). JAK1 association can also be inferred from the presence of a JAK1 binding domain in IL20RA that has been demonstrated to be a JAK1 binding site in several related interleukin receptors including IL22RA1 and IL10RA (Ferrao et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
14764663	Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2 Baurin, VV, Lewis-Antes, A, Shah, NK, Dumoutier, L, Zdanov, A, Anantha, S, Smirnov, SV, Sheikh, F, Renauld, JC, Dickensheets, H, Donnelly, RP, Kotenko, SV	J. Immunol.	2004