Reactome | IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3

IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3

Stable Identifier

R-HSA-8987070

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

STAT3 is phosphorylated by IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 activated receptor complex, STAT3 is phosphorylated by the IL22 activated receptor complex

ReviewStatus

5/5

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IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3

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Signal transducer and activator of transcription 3 (STAT3) is phosphorylated by the Interleukin-22 (IL22) receptor complex (Lejeune et al. 2002, Dumoutier et al. 2009, Lindemanns et al. 2015), which consists of IL22, phosphorylated Interleukin-22 receptor subunit alpha-1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2) and STAT3 (Meng et al. 2010, Sestito et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21098725	STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation Albanesi, C, Cianfarani, F, Scarponi, C, Sestito, R, Girolomoni, G, Cavani, A, Failla, CM, Madonna, S	FASEB J.	2011