Reactome | IL24:IL22RA1:p-JAK1:IL20RB binds STAT3

IL24:IL22RA1:p-JAK1:IL20RB binds STAT3

Stable Identifier

R-HSA-8987063

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

STAT3 binds to IL24:IL22RA1:p-JAK1:IL20RB, STAT3 binds to IL24:IL22RA1:p-JAK1:IL20RB

ReviewStatus

5/5

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Signal transducer and activator of transcription 3 (STAT3) is believed to bind the Interleukin-24 (IL24) receptor complex (Parrish Novak et al. 2002, Wang et al. 2002, Andoh et al. 2009). There are two forms of the IL24 receptor. The receptor complex represented here consists of IL24, Interleukin 22 receptor subunit alpha 1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB). Both forms of the IL24 receptor can activate STAT3 (Dumoutier et al. 2001, Wang et al. 2002). Based on the consensus understanding of JAK/STAT signaling, STAT3 activation is very likely to be preceded by STAT3 binding to the IL24 receptor.

This is a black box event because STAT3 binding is inferred as a prerequisite for STAT3 phosphorylation, based on STAT3 binding by the related IL10 receptor (Riley et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
11706020	Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 Wang, M, Tan, Z, Zhang, R, Kotenko, SV, Liang, P	J. Biol. Chem.	2002
19535621	Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease Andoh, A, Shioya, M, Nishida, A, Bamba, S, Tsujikawa, T, Kim-Mitsuyama, S, Fujiyama, Y	J. Immunol.	2009
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA	J Biol Chem	2002