Reactome | p-STAT3 dimer translocates from cytosol to nucleoplasm

p-STAT3 dimer translocates from cytosol to nucleoplasm

Stable Identifier

R-HSA-8987052

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

Synonyms

p-STAT3 dimer translocates from cytoplasm to the nucleous after IL24 stimulus

ReviewStatus

5/5

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p-STAT3 dimer translocates from cytosol to nucleoplasm

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Phosphorylated Signal transducer and activator of transcription 3 (STAT3) dimer translocates from the cytosol to the nucleoplasm after Interleukin-24 (IL24) stimulus (in BHK570 cells). Signal transducer and activator of transcription 1 alpha/beta (STAT1) was also translocated but only at high Interleukin-20 (IL20) doses (Parrish-Novak et al. 2002).
This is a black box event because the mechanism of translocation is not fully represented and may not require STAT3 dimer formation, but it can be inferred from the pattern of other Interleukins as IL10 signaling cascade (Niemand et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA	J Biol Chem	2002