Phosphorylated Signal transducer and activator of transcription 3 (STAT3) dimer translocates from the cytosol to the nucleoplasm after Interleukin-24 (IL24) stimulus (in BHK570 cells). Signal transducer and activator of transcription 1 alpha/beta (STAT1) was also translocated but only at high Interleukin-20 (IL20) doses (Parrish-Novak et al. 2002). This is a black box event because the mechanism of translocation is not fully represented and may not require STAT3 dimer formation, but it can be inferred from the pattern of other Interleukins as IL10 signaling cascade (Niemand et al. 2003).
Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA
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