Reactome | IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

Stable Identifier

R-HSA-8987042

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

TYK1 and JAK1 are phosphorylated by IL22:IL22RA1:JAK1:IL10RB:TYK2 receptor complex

ReviewStatus

5/5

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IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

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Inferred from rat, mouse, human :Tyrosine protein kinase JAK1 (JAK1) and Non-receptor tyrosine-protein kinase TYK2 (TYK2) are believed to be phosphorylated after Interleukin-22 interacts with its receptor. The receptor is a complex formed by Interleukin-22 receptor subunit alpha-1 (IL22RA1), JAK1, Interleukin-10 receptor subunit beta (IL10RB) and TYK2 (Lejeune et al. 2002, Sabat et al. 2014). This is a black-box event because the JAK1/TYK2 coordinates phosphorylated after IL22 stimulus are unknown.

Literature References

PubMed ID	Title	Journal	Year
12087100	Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10 Constantinescu, S, Schuringa, JJ, Dumoutier, L, Kruijer, W, Renauld, JC, Lejeune, D	J. Biol. Chem.	2002