IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1

Stable Identifier
R-HSA-8987040
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
IFNLR1 is phosphorylated by IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 activated receptor complex
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Interferon lambda receptor 1 receptor (IFNLR1, IL28RA) is believed to be phosphorylated by the Interferon lambda-1 (IFNL1 or IL29) complex (Sheppard et al. 2003). This complex is formed by IFNL1, IFNLR1, which is associated with phosphorylated Tyrosine protein kinase JAK1 (JAK1) and Interleukin 10 receptor beta (IL10RB), which is associated with phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2). IFNL1 induced Signal transducer and activator of transcription 2 (STAT2) tyrosine phosphorylation but not that of other STATs is at least partly mediated by IFNLR1 tyrosines 343 and 517 (Dumoutier et al. 2004). This is a black box event because there is not enough evidence to associate specific tyrosines with the binding of STATs and because the phosphorylation of these tyrosines is inferred from the STAT signaling mechanisms of related receptors.

Literature References
PubMed ID Title Journal Year
15166220 Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling (Dumoutier et al. ).

Dumoutier, L, Tounsi, A, Michiels, T, Sommereyns, C, Kotenko, SV, Renauld, JC

J. Biol. Chem. 2004
12469119 IL-28, IL-29 and their class II cytokine receptor IL-28R

Sheppard, P, Kindsvogel, W, Xu, W, Henderson, K, Schlutsmeyer, S, Whitmore, TE, Kuestner, R, Garrigues, U, Birks, C, Roraback, J, Ostrander, C, Dong, D, Shin, J, Presnell, S, Fox, B, Haldeman, B, Cooper, E, Taft, D, Gilbert, T, Grant, FJ, Tackett, M, Krivan, W, McKnight, G, Clegg, C, Foster, D, Klucher, KM

Nat Immunol 2003
Participants
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Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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