Reactome | IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1

IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1

Stable Identifier

R-HSA-8987040

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

IFNLR1 is phosphorylated by IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 activated receptor complex

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interferon lambda receptor 1 receptor (IFNLR1, IL28RA) is believed to be phosphorylated by the Interferon lambda-1 (IFNL1 or IL29) complex (Sheppard et al. 2003). This complex is formed by IFNL1, IFNLR1, which is associated with phosphorylated Tyrosine protein kinase JAK1 (JAK1) and Interleukin 10 receptor beta (IL10RB), which is associated with phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2). IFNL1 induced Signal transducer and activator of transcription 2 (STAT2) tyrosine phosphorylation but not that of other STATs is at least partly mediated by IFNLR1 tyrosines 343 and 517 (Dumoutier et al. 2004). This is a black box event because there is not enough evidence to associate specific tyrosines with the binding of STATs and because the phosphorylation of these tyrosines is inferred from the STAT signaling mechanisms of related receptors.

Literature References

PubMed ID	Title	Journal	Year
12469119	IL-28, IL-29 and their class II cytokine receptor IL-28R Sheppard, P, Kindsvogel, W, Xu, W, Henderson, K, Schlutsmeyer, S, Whitmore, TE, Kuestner, R, Garrigues, U, Birks, C, Roraback, J, Ostrander, C, Dong, D, Shin, J, Presnell, S, Fox, B, Haldeman, B, Cooper, E, Taft, D, Gilbert, T, Grant, FJ, Tackett, M, Krivan, W, McKnight, G, Clegg, C, Foster, D, Klucher, KM	Nat Immunol	2003
15166220	Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling (Dumoutier et al. ). Dumoutier, L, Tounsi, A, Michiels, T, Sommereyns, C, Kotenko, SV, Renauld, JC	J. Biol. Chem.	2004