Reactome | JAK1 binds IL20RA

JAK1 binds IL20RA

Stable Identifier

R-HSA-8987039

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Tyrosine protein kinase JAK1 (JAK1) binds Interleukin-20 receptor subunit alpha (IL20RA). JAK1 coimmunoprecipitates with several class II receptor complexes including Interferon gamma receptor 1 (IFNGR1), Interferon alpha/beta receptor 2 (IFNAR2), Interferon lambda receptor 1 (IFNLR1), Interleukin-10 receptor subunit alpha (IL10RA), Interleukin-22 receptor subunit alpha 1 (IL22RA1) and Interleukin-20 receptor subunit alpha (IL20RA), leading to the suggestion that Class II receptors may have a common sequence motif for JAK recognition (Ferrao et al. 2016). This is a black box event because JAK1 binding to IL20RA is inferred from binding to related receptors and subsequent JAK/STAT signaling events (Ferrao et al 2016, Hann et al. 2006, Murakami et al. 1991).

Literature References

PubMed ID	Title	Journal	Year
27133025	The Structural Basis for Class II Cytokine Receptor Recognition by JAK1 Franke, Y, Lupardus, PJ, Tam, C, Ferrao, R, Ho, H, Wallweber, HJ, Quinn, J	Structure	2016
16750817	Jaks and cytokine receptors--an intimate relationship Behrmann, I, Margue, C, Kreis, S, Haan, C	Biochem. Pharmacol.	2006
1662392	Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family Kishimoto, T, Taga, T, Murakami, M, Hamaguchi, M, Hibi, M, Narazaki, M, Yasukawa, K, Yawata, H	Proc Natl Acad Sci U S A	1991