Phosphorylated Signal transducer and activator of transcription 1 alpha/beta (STAT1), Phosphorylated Signal transducer and activator of transcription 2 (STAT2) , Phosphorylated Signal transducer and activator of transcription 3 (STAT3) , Phosphorylated Signal transducer and activator of transcription 4 (STAT4) and Phosphorylated Signal transducer and activator of transcription 5 (STAT5) are believed to dissociate from the receptor complex (Dumoutier et al. 2004, Novak et al. 2008). This is a black-box event because dissociation is inferred from other interleukin signaling cascades such as Interleukin-10 (Niemand et al. 2003, Braum et al. 2013, Xiong et al. 2014, Sheikh et al. 2006, You et al. 2013) where dissociation occurs before STAT dimerization and translocation to the nucleus.