Phosphorylated Signal transducer and activator of transcription 1 alpha/beta (STAT1), Phosphorylated Signal transducer and activator of transcription 2 (STAT2) , Phosphorylated Signal transducer and activator of transcription 3 (STAT3) , Phosphorylated Signal transducer and activator of transcription 4 (STAT4) and Phosphorylated Signal transducer and activator of transcription 5 (STAT5) are believed to dissociate from the receptor complex (Dumoutier et al. 2004, Novak et al. 2008). This is a black-box event because dissociation is inferred from other interleukin signaling cascades such as Interleukin-10 (Niemand et al. 2003, Braum et al. 2013, Xiong et al. 2014, Sheikh et al. 2006) where dissociation occurs before STAT dimerization and translocation to the nucleus.