Reactome | IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1

IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1

Stable Identifier

R-HSA-8987012

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

JAK1 is phosphorylated by IL20,IL24:IL22RA1:JAK1:IL20RB receptor complex, JAK1 is phosphorylated after il22r il20rb receptor interacts with il20 or il24, JAK1 is phosphorylated after IL20 or IL24 and IL22RA1:JAK1:IL20RB receptor complex interaction

ReviewStatus

5/5

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IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1

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Tyrosine-protein kinase JAK1 (JAK1) is phosphorylated after Interleukin-24 (IL24) ligand interaction with its receptor. There are two IL24 receptors. One consists of Interleukin-20 receptor subunit alpha (IL20RA), Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB), the other, represented in this event, uses interleukin-22 receptor subunit alpha-1 (IL22RA1) instead of IL20RA (Dumoutier et al. 2001, Wang et al. 2002). IL22RA1 can bind JAK1 (Ferrao et al. 2016). IL24 can stimulate JAK1 phosphorylation in human colonic subepithelial myofibroblasts, where the components of both forms of the IL24 receptor are expressed (Andoh et al. 2009). It has been demonstrated that both forms of the IL24 receptor can activate STAT3 (Dumoutier et al. 2001, Wang et al. 2002). Based on the consensus understanding of JAK/STAT signaling, STAT3 activation is very likely to be preceded by JAK1 phosphorylation and it is therefore likely that JAK1 is phosphorylated in both forms of the IL24 receptor. This is a black box event because it has not been established that both forms of the IL24 receptor are involved in JAK1 phosphorylation.

Literature References

PubMed ID	Title	Journal	Year
11706020	Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 Wang, M, Tan, Z, Zhang, R, Kotenko, SV, Liang, P	J. Biol. Chem.	2002
19535621	Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease Andoh, A, Shioya, M, Nishida, A, Bamba, S, Tsujikawa, T, Kim-Mitsuyama, S, Fujiyama, Y	J. Immunol.	2009
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA	J Biol Chem	2002