p-STAT1 dimerizes

Stable Identifier
R-HSA-8987007
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-STAT1 dimerizes after IL24 stimulus, p-STAT1 dimerizes after receptor activation
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p-STAT1 dimerizes
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Signal transducer and activator of transcription 1alpha/beta (STAT1) is believed to dimerize after it dissociates from the Interleukin-24 (IL24) receptor complex. This is a black box event because dimerization is inferred from STAT1 dimerization in response to Interferon gamma (IFNG) (Wehinger et al. 1996) and the observed translocation of STAT1 to the nucleus in response to IL24 (Parrish-Novak et al. 2002).

Literature References
PubMed ID Title Journal Year
8830676 IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes

Wehinger, J, Gouilleux, F, Groner, B, Finke, J, Mertelsmann, R, Weber-Nordt, RM

FEBS Lett. 1996
12351624 Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions

Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA

J Biol Chem 2002
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Orthologous Events
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p-STAT1 dimerizes (Drosophila melanogaster)
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Authored
Duenas, C  (2017-03-16)
Reviewed
Datta, SK  (2017-11-15)
Created
Duenas, C  (2017-05-05)