Reactome | IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2

IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2

Stable Identifier

R-HSA-8986994

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

JAK1 and TYK2 are phosphorylated by IL26:IL20RA:JAK1:IL10RB:TYK2 receptor complex, JAK1 and TYK2 are phosphorylated after il26 il26 receptor interaction

ReviewStatus

5/5

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IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2

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Tyrosine-protein kinase JAK1 (JAK1) and Non-receptor tyrosine-protein kinase TYK2 (TYK2) are believed to be phosphorylated after Interleukin-26 (IL26) ligand/receptor interaction. The Interleukin-10 receptor subunit beta (IL10RB) component of the IL26 receptor is also a component of the IL10 receptor, where it associates with TYK2 (Finbloom & Winestock 1995). The Interleukin-20 receptor subunit alpha (IL20RA) component of the IL26 receptor, like the Interleukin-10 receptor subunit alpha (IL10RA) subunit of the IL10 receptor, is a type II cytokine receptor, suggested by homology with IL10RA to be capable of binding JAK1 (Ferrao et al. 2016). Structural models of the IL10 receptor suggest that the space between the two receptor subunits is occupied by JAK1 and TYK2 (Yoon et al. 2006, 2010). Taken together, these observations suggest that IL26 receptor signaling involves JAK1 and TYK2 activation.

Literature References

PubMed ID	Title	Journal	Year
7543512	IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes Finbloom, DS, Winestock, KD	J. Immunol.	1995
16982608	Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex Yoon, SI, Logsdon, NJ, Sheikh, F, Donnelly, RP, Walter, MR	J. Biol. Chem.	2006
14764663	Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2 Sheikh, F, Baurin, VV, Lewis-Antes, A, Shah, NK, Smirnov, SV, Anantha, S, Dickensheets, H, Dumoutier, L, Renauld, JC, Zdanov, A, Donnelly, RP, Kotenko, SV	J. Immunol.	2004
20462497	Structure and mechanism of receptor sharing by the IL-10R2 common chain Yoon, SI, Jones, BC, Logsdon, NJ, Harris, BD, Deshpande, A, Radaeva, S, Halloran, BA, Gao, B, Walter, MR	Structure	2010