IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5

Stable Identifier
R-HSA-8986985
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
STAT1 is phosphorylated by IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 activated receptor complex, STAT1 is phosphorylated after IL29-IL29 receptor interaction
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IFNL1 can induce phosphorylation of Signal transducer and activator of transcription 1 alpha/beta (STAT1), Signal transducer and activator of transcription 3 (STAT2), Signal transducer and activator of transcription 3 (STAT3), Signal transducer and activator of transcription 4 (STAT4) and Signal transducer and activator of transcription 5 (STAT5) (Dumoutier et al. 2004, Novak et al. 2008, Dickensheets et al. 2013) via stimulation of the Interferon lambda-1 (IFNL1) receptor complex. This complex consists of IFNL1, IFNLR1, which is associated with phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-10 receptor beta (IL10RB), which is associated with phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2) and STAT1.
This is a black-box event because direct evidence for STAT4 and 5 binding and activation is lacking (Jordan et al. 2007).

Literature References
PubMed ID Title Journal Year
18830264 A role for IFN-lambda1 in multiple myeloma B cell growth

Novak, AJ, Grote, DM, Ziesmer, SC, Rajkumar, V, Doyle, SE, Ansell, SM

Leukemia 2008
Participants
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Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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