IL26:IL20RA:JAK1 binds IL10RB:TYK2

Stable Identifier
Reaction [binding]
Homo sapiens
IL10RB:TYK2 receptor complex binds IL26:IL20RA:JAK1 receptor complex, IL26:IL20RA complex binds IL10RB
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The interaction of Interleukin-26 (IL26) with Interleukin-20 receptor subunit alpha (IL20RA) induces conformational changes that allow it to bind Interleukin-10 receptor subunit beta (IL10RB) (Yoon et al. 2006, 2010), which is pre associated with Non-receptor tyrosine-protein kinase TYK2 (TYK2) (another citation).

Literature References
PubMed ID Title Journal Year
16982608 Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex

Logsdon, NJ, Yoon, SI, Sheikh, F, Donnelly, RP, Walter, MR

J. Biol. Chem. 2006
14764663 Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2

Baurin, VV, Lewis-Antes, A, Shah, NK, Dumoutier, L, Zdanov, A, Anantha, S, Smirnov, SV, Sheikh, F, Renauld, JC, Dickensheets, H, Donnelly, RP, Kotenko, SV

J. Immunol. 2004
20462497 Structure and mechanism of receptor sharing by the IL-10R2 common chain

Yoon, SI, Radaeva, S, Jones, BC, Gao, B, Logsdon, NJ, Halloran, BA, Deshpande, A, Harris, BD, Walter, MR

Structure 2010
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