Reactome | IL26 binds IL20RA:JAK1

IL26 binds IL20RA:JAK1

Stable Identifier

R-HSA-8986446

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Synonyms

Interleukin-26 binds Interleukin-26 receptor

ReviewStatus

5/5

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Interleukin 26 is believed to bind to its receptor complex which is formed by Interleukin 20 receptor subunit alpha and JAK1 (Yoon et al. 2006, Yoon et al. 2010, Sheikh et al. 2004). This is a black box event because constitutive pre association of JAK1 with IL20RA is inferred from the observation that IL20RA belongs to the cytokine receptor type II family, which has a common domain necessary for binding of JAK1 and release signaling (Ferrao et al. 2016, Hor et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14764663	Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2 Baurin, VV, Lewis-Antes, A, Shah, NK, Dumoutier, L, Zdanov, A, Anantha, S, Smirnov, SV, Sheikh, F, Renauld, JC, Dickensheets, H, Donnelly, RP, Kotenko, SV	J. Immunol.	2004
15178681	The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains Bauer, F, Fickenscher, H, Wittmann, S, Dumoutier, L, Pirzer, H, de Waal Malefyt, R, Hör, S, Sticht, H, Renauld, JC	J. Biol. Chem.	2004
20462497	Structure and mechanism of receptor sharing by the IL-10R2 common chain Yoon, SI, Radaeva, S, Jones, BC, Gao, B, Logsdon, NJ, Halloran, BA, Deshpande, A, Harris, BD, Walter, MR	Structure	2010