IL26 binds IL20RA:JAK1

Stable Identifier
Reaction [uncertain]
Homo sapiens
Interleukin-26 binds Interleukin-26 receptor
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Interleukin 26 is believed to bind to its receptor complex which is formed by Interleukin 20 receptor subunit alpha and JAK1 (Yoon et al. 2006, Yoon et al. 2010, Sheikh et al. 2004). This is a black box event because constitutive pre association of JAK1 with IL20RA is inferred from the observation that IL20RA belongs to the cytokine receptor type II family, which has a common domain necessary for binding of JAK1 and release signaling (Ferrao et al. 2016, Hor et al. 2004).
Literature References
PubMed ID Title Journal Year
14764663 Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2

Baurin, VV, Lewis-Antes, A, Shah, NK, Dumoutier, L, Zdanov, A, Anantha, S, Smirnov, SV, Sheikh, F, Renauld, JC, Dickensheets, H, Donnelly, RP, Kotenko, SV

J. Immunol. 2004
15178681 The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains

Bauer, F, Fickenscher, H, Wittmann, S, Dumoutier, L, Pirzer, H, de Waal Malefyt, R, Hör, S, Sticht, H, Renauld, JC

J. Biol. Chem. 2004
20462497 Structure and mechanism of receptor sharing by the IL-10R2 common chain

Yoon, SI, Radaeva, S, Jones, BC, Gao, B, Logsdon, NJ, Halloran, BA, Deshpande, A, Harris, BD, Walter, MR

Structure 2010
Orthologous Events
Cite Us!