Reactome | IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5

IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5

Stable Identifier

R-HSA-8985988

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

STAT1, STAT3 or STAT5 are phosphorylated by IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3

ReviewStatus

5/5

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IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5

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Signal transducer and activator of transcription 1-alpha/beta (STAT1), STAT3, and STAT5A/STAT5B (collectively termed STAT5) are tyrosine phosphorylated in tyrosine residues 701, 705 and 649 respectively, in response to IL9 stimulation (Nizsalóczki et al. 2014, Yamasaki et al. 2010, Demoulin et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
25297818	Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells Nizsalóczki, E, Nagy, P, Csomós, I, Waldmann, TA, Goldman, CK, Fazekas, Z, Bodnár, A, Mátyus, L, Vámosi, G, Damjanovich, S	Chemphyschem	2014
11306517	Interleukin-9 (IL-9) induces cell growth arrest associated with sustained signal transducer and activator of transcription activation in lymphoma cells overexpressing the IL-9 receptor Demoulin, JB, Van Snick, J, Renauld, JC	Cell Growth Differ.	2001
20169197	IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells Koussih, L, Yamasaki, A, Halayko, AJ, Saleh, A, Muro, S, Gounni, AS	PLoS ONE	2010