p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus

Stable Identifier
Reaction [uncertain]
Homo sapiens
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The Signal transducer and activator of transcription 1-alpha/beta (STAT1) -Signal transducer and activator of transcription 3 (STAT3) complex translocates from the cytosol to the nucleus. Interleukin-9 (IL9) stimulation induces STAT3 nuclear translocation and binding in vivo to the Eotaxin (CCL11) promoter (Yamasaki et al. 2010, Gounni et al. 2004). Interleukin-9 (IL9) stimulation induces mucin5AC, junB and c-myc transcription (Longphre et al. 1999, Kang et al, 1995).

This is a black box event because this evidence shows STAT3 translocation, but not translocation of a STAT1:STAT3 dimer.
Literature References
PubMed ID Title Journal Year
10562299 Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells

Basbaum, C, Wenzel, S, Li, D, Bice, DE, Drori, E, Longphre, M, Redman, T, Gallup, M, OrdoƱez, CL, Fahy, JV

J. Clin. Invest. 1999
7775604 Activation of junB and c-myc primary response genes by interleukin 9 in a human factor-dependent cell line

Kang, LY, Yang, YC

J. Cell. Physiol. 1995
20169197 IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells

Koussih, L, Yamasaki, A, Halayko, AJ, Saleh, A, Muro, S, Gounni, AS

PLoS ONE 2010
Orthologous Events
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