p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus

Stable Identifier
R-HSA-8985981
Type
Reaction [uncertain]
Species
Homo sapiens
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The Signal transducer and activator of transcription 1-alpha/beta (STAT1) -Signal transducer and activator of transcription 3 (STAT3) complex translocates from the cytosol to the nucleus. Interleukin-9 (IL9) stimulation induces STAT3 nuclear translocation and binding in vivo to the Eotaxin (CCL11) promoter (Yamasaki et al. 2010, Gounni et al. 2004). Interleukin-9 (IL9) stimulation induces mucin5AC, junB and c-myc transcription (Longphre et al. 1999, Kang et al, 1995).

This is a black box event because this evidence shows STAT3 translocation, but not translocation of a STAT1:STAT3 dimer.

Literature References
PubMed ID Title Journal Year
7775604 Activation of junB and c-myc primary response genes by interleukin 9 in a human factor-dependent cell line

Kang, LY, Yang, YC

J. Cell. Physiol. 1995
10562299 Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells

Longphre, M, Li, D, Gallup, M, Drori, E, OrdoƱez, CL, Redman, T, Wenzel, S, Bice, DE, Fahy, JV, Basbaum, C

J. Clin. Invest. 1999
20169197 IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells

Yamasaki, A, Saleh, A, Koussih, L, Muro, S, Halayko, AJ, Gounni, AS

PLoS ONE 2010
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