IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3

Stable Identifier
R-HSA-8985973
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Interleukin-9 receptor (IL9R) is phosphorylated after ligand-receptor interaction. IL9R tyrosine-116 is required for Interleukin-9 (IL9) mediated receptor tyrosine phosphorylation and STAT activation (Demoulin et al. 1996, Bauer et al. 1998).

This is a black box event because it is has not been established which of the JAKs phosphorylates IL9R.

Literature References
PubMed ID Title Journal Year
9535918 Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis

Bauer, JH, Liu, KD, You, Y, Lai, SY, Goldsmith, MA

J. Biol. Chem. 1998
8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9

Demoulin, JB, Uyttenhove, C, Van Roost, E, DeLestré, B, Donckers, D, Van Snick, J, Renauld, JC

Mol. Cell. Biol. 1996
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