Reactome | IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3

IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3

Stable Identifier

R-HSA-8985973

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3

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Interleukin-9 receptor (IL9R) is phosphorylated after ligand-receptor interaction. IL9R tyrosine-407 is required for Interleukin-9 (IL9) mediated receptor tyrosine phosphorylation and STAT activation (Demoulin et al. 1996, Bauer et al. 1998).

This is a black box event because it is has not been established which of the JAKs phosphorylates IL9R.

Literature References

PubMed ID	Title	Journal	Year
8756628	A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 Uyttenhove, C, Demoulin, JB, Van Snick, J, Van Roost, E, Donckers, D, DeLestré, B, Renauld, JC	Mol. Cell. Biol.	1996
9535918	Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis You, Y, Bauer, JH, Lai, SY, Liu, KD, Goldsmith, MA	J. Biol. Chem.	1998