p-Y694-STAT5A, p-STAT5B dimerizes

Stable Identifier
R-HSA-8985950
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-Y694-STAT5A, p-STAT5B dimerizes
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After phosphorylation on tyrosine-701, STAT1 forms an antiparallel dimer which exposes its nuclear import signal, causing translocation into the nucleus (Sekimoto et al. 1997, reviewed in McBride and Reich 2003). STAT1 is phosphorylated and imported into the nucleus in response to low-shear stress, a form of turbulent flow across endothelial cells (Lv et al. 2024).
Literature References
PubMed ID Title Journal Year
9535918 Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis

You, Y, Bauer, JH, Lai, SY, Liu, KD, Goldsmith, MA

J. Biol. Chem. 1998
Participants
Input
Output
Participates
as an event of
Orthologous Events
p-Y694-STAT5A, p-STAT5B dimerizes (Bos taurus)
p-Y694-STAT5A, p-STAT5B dimerizes (Caenorhabditis elegans)
p-Y694-STAT5A, p-STAT5B dimerizes (Canis familiaris)
p-Y694-STAT5A, p-STAT5B dimerizes (Danio rerio)
p-Y694-STAT5A, p-STAT5B dimerizes (Dictyostelium discoideum)
p-Y694-STAT5A, p-STAT5B dimerizes (Drosophila melanogaster)
p-Y694-STAT5A, p-STAT5B dimerizes (Gallus gallus)
p-Y694-STAT5A, p-STAT5B dimerizes (Mus musculus)
p-Y694-STAT5A, p-STAT5B dimerizes (Rattus norvegicus)
p-Y694-STAT5A, p-STAT5B dimerizes (Sus scrofa)
p-Y694-STAT5A, p-STAT5B dimerizes (Xenopus tropicalis)
Authored
Duenas, C  (2017-04-21)
Reviewed
Meldal, BH  (2016-01-28)
Limon, PL  (2018-04-27)
Created
Duenas, C  (2017-04-21)
Cite Us!