RUNX2 and RB1 bind the COL1A1 gene promoter

Stable Identifier
R-HSA-8985627
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX2 and RB1 bind the COL1A1 gene promoter
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Based on studies in mice, the complex of RUNX2 and RB1 binds to RUNX2-binding elements in the promoter of the COL1A1 gene encoding Collagen alpha-1(I) chain (Kern et al. 2001, Calo et al. 2010). RUNX2 binding sites are conserved in the human COL1A1 gene promoter.
Literature References
PubMed ID Title Journal Year
11106645 Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes

Karsenty, G, Starbuck, M, Kern, B, Shen, J

J. Biol. Chem. 2001
20686481 Rb regulates fate choice and lineage commitment in vivo

Berman, SD, Quintero-Estades, JA, Calo, E, Lees, JA, Danielian, PS, Nedelcu, S

Nature 2010
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Runx2 and Rb1 bind the Col1a1 gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2017-04-18)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-04-18)
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