Reactome | RUNX2 and RB1 bind the COL1A1 gene promoter

RUNX2 and RB1 bind the COL1A1 gene promoter

Stable Identifier

R-HSA-8985627

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - RUNX2 regulates bone development (Homo sapiens)
        
        RUNX2 regulates osteoblast differentiation (Homo sapiens)
        
        RUNX2 and RB1 bind the COL1A1 gene promoter (Homo sapiens)

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RUNX2 and RB1 bind the COL1A1 gene promoter

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Based on studies in mice, the complex of RUNX2 and RB1 binds to RUNX2-binding elements in the promoter of the COL1A1 gene encoding Collagen alpha-1(I) chain (Kern et al. 2001, Calo et al. 2010). RUNX2 binding sites are conserved in the human COL1A1 gene promoter.

Literature References

PubMed ID	Title	Journal	Year
11106645	Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes Karsenty, G, Starbuck, M, Kern, B, Shen, J	J. Biol. Chem.	2001
20686481	Rb regulates fate choice and lineage commitment in vivo Berman, SD, Quintero-Estades, JA, Calo, E, Lees, JA, Danielian, PS, Nedelcu, S	Nature	2010