SLIT2-bound ROBO1 binds MYO9B

Stable Identifier
R-HSA-8985591
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ROBO1, bound to SLIT2, binds to the RHO GAP protein MYO9B. The interaction involves all four cytoplasmic conserved (CC) motifs in the intracellular domain of ROBO1 and the RHO GAP domain of MYO9B. Binding to ROBO1 inhibits the RHOA GAP activity of MYO9B and increases the amount of active GTP-bound RHOA (RHOA:GTP). ROBO1-mediated inhibition of MYO9B and the resulting increase in RHOA activity is implicated as a negative regulator of invasiveness of lung cancer cells (Kong et al. 2015).

Literature References
PubMed ID Title Journal Year
26529257 Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

Kong, R, Yi, F, Wen, P, Liu, J, Chen, X, Ren, J, Li, X, Shang, Y, Nie, Y, Wu, K, Fan, D, Zhu, L, Feng, W, Wu, JY

J. Clin. Invest. 2015
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created