SLIT2-bound ROBO1 binds MYO9B

Stable Identifier
Reaction [binding]
Homo sapiens
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ROBO1, bound to SLIT2, binds to the RHO GAP protein MYO9B. The interaction involves all four cytoplasmic conserved (CC) motifs in the intracellular domain of ROBO1 and the RHO GAP domain of MYO9B. Binding to ROBO1 inhibits the RHOA GAP activity of MYO9B and increases the amount of active GTP-bound RHOA (RHOA:GTP). ROBO1-mediated inhibition of MYO9B and the resulting increase in RHOA activity is implicated as a negative regulator of invasiveness of lung cancer cells (Kong et al. 2015).

Literature References
PubMed ID Title Journal Year
26529257 Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

Kong, R, Yi, F, Wen, P, Liu, J, Chen, X, Ren, J, Li, X, Shang, Y, Nie, Y, Wu, K, Fan, D, Zhu, L, Feng, W, Wu, JY

J. Clin. Invest. 2015
Participant Of
Orthologous Events