Reactome | RUNX2 and RB1 bind the BGLAP gene promoter

RUNX2 and RB1 bind the BGLAP gene promoter

Stable Identifier

R-HSA-8985485

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - RUNX2 regulates bone development (Homo sapiens)
        
        RUNX2 regulates osteoblast differentiation (Homo sapiens)
        
        RUNX2 and RB1 bind the BGLAP gene promoter (Homo sapiens)

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RUNX2 and RB1 bind the BGLAP gene promoter

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The complex of RUNX2 and RB1 binds the promoter of the BGLAP gene, encoding osteocalcin (Thomas et al. 2001, Calo et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
11545733	The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation Thomas, DM, Wang, WF, Carty, SA, Forrester, WC, Lee, JS, Hinds, PW, Piscopo, DM	Mol. Cell	2001
20686481	Rb regulates fate choice and lineage commitment in vivo Berman, SD, Quintero-Estades, JA, Calo, E, Lees, JA, Danielian, PS, Nedelcu, S	Nature	2010