NKX3-2 binds RUNX2 gene promoter

Stable Identifier
R-HSA-8985293
Type
Reaction [binding]
Species
Homo sapiens
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Based on studies in mice, the homeobox protein NKX3-2 (BAPX1), required for embryonic development of the axial skeleton (Tribioli and Lufkin 1999), binds the distal (P1) promoter of the RUNX2 gene (Lengner et al. 2005). NKX3-2 binding sites are conserved in the human RUNX2 promoter.

Literature References
PubMed ID Title Journal Year
15703179 Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation

Lengner, CJ, Hassan, MQ, Serra, RW, Lepper, C, van Wijnen, AJ, Stein, JL, Lian, JB, Stein, GS

J. Biol. Chem. 2005
10572046 The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen

Tribioli, C, Lufkin, T

Development 1999
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