Reactome | ABCE1 binds RNASEL

ABCE1 binds RNASEL

Stable Identifier

R-HSA-8985201

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ATP-binding cassette sub-family E member 1 (ABCE1, aka RNase L inhibitor, RLI) is a member of the ATP-binding cassette transporters which express in the cytoplasm and the nuclear membrane. ABCE1 is induced during viral infections (Bisbal C et al. 1995; Martinand C et al. 1998, 1999). ABCE1 (RLI) was shown to associate with RNase L inhibiting the endoribonuclease activity of RNase L, thus antagonising the anti-viral effect of the IFN-regulated 2'-5' oligoadenylate/RNase L pathway (Bisbal C et al. 1995; Martinand C et al. 1998, 1999). Furthermore, overexpression or knockdown of ABCE1 (RLI) has inhibitory or promoting effects on the binding of RNase L to 2'-5' oligoadenylates, rRNA cleavage, destabilization of mitochondrial mRNA, antiviral activity, and antitumor activity (Martinand C et al. 1998, 1999; Le Roy F et al. 2001; Malathi K et al. 2004; Huang B et al. 2014; Tian Y et al. 2016). Aside from its role as an RNase-L inhibitor, ABCE1 is believed to be involved in translation termination and ribosome recycling (Dong J et al. 2004; Chen ZQ et al. 2006; Khoshnevis S et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
11265282	The 2-5A/RNase L pathway and inhibition by RNase L inhibitor (RLI) Salehzada, T, Martinand, C, Bisbal, C, Lebleu, B, Le Roy, F, Silhol, M	Methods Mol. Biol.	2001
7539425	Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway Salehzada, T, Martinand, C, Bisbal, C, Lebleu, B, Silhol, M	J. Biol. Chem.	1995
9847332	RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells Salehzada, T, Martinand, C, Bisbal, C, Lebleu, B, Silhol, M, Montavon, C	J. Virol.	1999