ABCE1 binds RNASEL

Stable Identifier
R-HSA-8985201
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ATP-binding cassette sub-family E member 1 (ABCE1, aka RNase L inhibitor, RLI) is a member of the ATP-binding cassette transporters which express in the cytoplasm and the nuclear membrane. ABCE1 is induced during viral infections (Bisbal C et al. 1995; Martinand C et al. 1998, 1999). ABCE1 (RLI) was shown to associate with RNase L inhibiting the endoribonuclease activity of RNase L, thus antagonising the anti-viral effect of the IFN-regulated 2'-5' oligoadenylate/RNase L pathway (Bisbal C et al. 1995; Martinand C et al. 1998, 1999). Furthermore, overexpression or knockdown of ABCE1 (RLI) has inhibitory or promoting effects on the binding of RNase L to 2'-5' oligoadenylates, rRNA cleavage, destabilization of mitochondrial mRNA, antiviral activity, and antitumor activity (Martinand C et al. 1998, 1999; Le Roy F et al. 2001; Malathi K et al. 2004; Huang B et al. 2014; Tian Y et al. 2016). Aside from its role as an RNase-L inhibitor, ABCE1 is believed to be involved in translation termination and ribosome recycling (Dong J et al. 2004; Chen ZQ et al. 2006; Khoshnevis S et al. 2010).

Literature References
PubMed ID Title Journal Year
7539425 Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway

Bisbal, C, Martinand, C, Silhol, M, Lebleu, B, Salehzada, T

J. Biol. Chem. 1995
11265282 The 2-5A/RNase L pathway and inhibition by RNase L inhibitor (RLI)

Bisbal, C, Salehzada, T, Silhol, M, Martinand, C, Le Roy, F, Lebleu, B

Methods Mol. Biol. 2001
9847332 RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells

Martinand, C, Montavon, C, Salehzada, T, Silhol, M, Lebleu, B, Bisbal, C

J. Virol. 1999
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