OAS2 binds viral dsRNA

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Respiratory syncytial virus
Locations in the PathwayBrowser
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The human oligoadenylate synthetase 2 (OAS2) is activated by double-stranded RNA (dsRNA) (Hovanessian AG et al. 1988; Behera AK et al. 2002; Kristiansen H et al. 2011).

Literature References
PubMed ID Title Journal Year
11980899 2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells

Mohapatra, SS, Lockey, RF, Kumar, M, Behera, AK

J. Biol. Chem. 2002
3350819 Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells

Robert, N, Hovanessian, AG, MariƩ, I, Laurent, AG, Svab, J, Chamaret, S

J. Biol. Chem. 1988
11986302 Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase

Sen, GC, Crabb, JW, Sarkar, SN, Miyagi, M

J. Biol. Chem. 2002
9880569 Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

Sarkar, SN, Sen, GC, Ghosh, A, Bandyopadhyay, S

J. Biol. Chem. 1999
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