OAS2 binds viral dsRNA

Stable Identifier
R-HSA-8985138
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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OAS2 binds viral dsRNA
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The human oligoadenylate synthetase 2 (OAS2) is activated by double-stranded RNA (dsRNA) (Hovanessian AG et al. 1988; Behera AK et al. 2002; Kristiansen H et al. 2011).
Literature References
PubMed ID Title Journal Year
11980899 2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells

Behera, AK, Kumar, M, Lockey, RF, Mohapatra, SS

J. Biol. Chem. 2002
3350819 Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells

Hovanessian, AG, Svab, J, Marié, I, Robert, N, Chamaret, S, Laurent, AG

J. Biol. Chem. 1988
11986302 Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase

Sarkar, SN, Miyagi, M, Crabb, JW, Sen, GC

J. Biol. Chem. 2002
9880569 Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

Sarkar, SN, Bandyopadhyay, S, Ghosh, A, Sen, GC

J. Biol. Chem. 1999
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Authored
Shamovsky, V  (2017-03-27)
Reviewed
D'Eustachio, P  (2017-12-02)
Silverman, RH  (2018-07-31)
Bergeron, HC  (2023-11-03)
Created
Shamovsky, V  (2017-04-12)
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