OAS2 binds viral dsRNA

Stable Identifier
R-HSA-8985138
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Respiratory syncytial virus
Compartment
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The human oligoadenylate synthetase 2 (OAS2) is activated by double-stranded RNA (dsRNA) (Hovanessian AG et al. 1988; Behera AK et al. 2002; Kristiansen H et al. 2011).

Literature References
PubMed ID Title Journal Year
3350819 Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells

Hovanessian, AG, Svab, J, MariƩ, I, Robert, N, Chamaret, S, Laurent, AG

J. Biol. Chem. 1988
11980899 2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells

Behera, AK, Kumar, M, Lockey, RF, Mohapatra, SS

J. Biol. Chem. 2002
11986302 Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase

Sarkar, SN, Miyagi, M, Crabb, JW, Sen, GC

J. Biol. Chem. 2002
9880569 Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

Sarkar, SN, Bandyopadhyay, S, Ghosh, A, Sen, GC

J. Biol. Chem. 1999
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