Reactome | RUNX2 binds MAF

RUNX2 binds MAF

Stable Identifier

R-HSA-8984994

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - RUNX2 regulates bone development (Homo sapiens)
        
        RUNX2 regulates osteoblast differentiation (Homo sapiens)
        
        RUNX2 binds MAF (Homo sapiens)

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Based on studies in mice, RUNX2 forms a complex with the transcription factor MAF. It is unknown whether MAF participates in this complex as a homodimer or a monomer. It is also unknown whether RUNX2 is bound to CBFB when in complex with MAF (Nishikawa et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20877012	Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation Nishikawa, K, Nakashima, T, Takeda, S, Isogai, M, Hamada, M, Kimura, A, Kodama, T, Yamaguchi, A, Owen, MJ, Takahashi, S, Takayanagi, H	J. Clin. Invest.	2010