IL12A gene transcription and translation

Stable Identifier
R-HSA-8984964
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin-35 (IL35) is a complex conformed by Interleukin-12 subunit alpha (IL12A) and Interleukin-27 subunit alpha (IL27). IL35 can induce heterodimers of Interleukin-6 receptor beta precursor (IL6ST) and Interleukin-12 receptor beta 2 (IL12RB2). Consequently, heteromeric Signal transducer and activator of transcription 1-alpha/beta (STAT1) and Signal transducer and activator of transcription 4 (STAT4) are phosphorylated. Subsequently, this STAT1:STAT4 complex can translocate into the nucleus and bind to promoter regions of IL12A thereby facilitating the protein expression. Thus, by inducing the expression of itself, a positive feedback regulation is achieved in the IL35 signalling pathway. This is a black box event because the intermediate steps of IL12A transcription/translation are omitted.

Literature References
PubMed ID Title Journal Year
22306691 The composition and signaling of the IL-35 receptor are unconventional

Collison, LW, Delgoffe, GM, Guy, CS, Vignali, KM, Chaturvedi, V, Fairweather, D, Satoskar, AR, Garcia, KC, Hunter, CA, Drake, CG, Murray, PJ, Vignali, DA

Nat. Immunol. 2012
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created
Cite Us!