p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor

Stable Identifier
R-HSA-8984023
Type
Reaction [omitted]
Species
Homo sapiens
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Interleukin 35 (IL35) can signal via IL35 receptors triggering the JAK/STAT pathway downstream. Signal transducer and activator of transcription 1 alpha/beta (STAT1) and Signal transducer and activator of transcription 3 alpha/beta (STAT3) bind to the JAK associated IL35 receptor complex and are activated via phosphorylations. Subsequently, phosphorylated p STAT1:p STAT3 dissociates from the receptor complex (Wang et al. 2014). This is a black box event because there is no literature evidence about the exact mechanism of the release of STAT1 and STAT3 from the receptor complex.

Literature References
PubMed ID Title Journal Year
24743305 Interleukin-35 induces regulatory B cells that suppress autoimmune disease

Wang, RX, Yu, CR, Dambuza, IM, Mahdi, RM, Dolinska, MB, Sergeev, YV, Wingfield, PT, Kim, SH, Egwuagu, CE

Nat. Med. 2014
24572363 IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Shen, P, Roch, T, Lampropoulou, V, O'Connor, RA, Stervbo, U, Hilgenberg, E, Ries, S, Dang, VD, Jaimes, Y, Daridon, C, Li, R, Jouneau, L, Boudinot, P, Wilantri, S, Sakwa, I, Miyazaki, Y, Leech, MD, McPherson, RC, Wirtz, S, Neurath, M, Hoehlig, K, Meinl, E, Grützkau, A, Grün, JR, Horn, K, Kühl, AA, Dörner, T, Bar-Or, A, Kaufmann, SH, Anderton, SM, Fillatreau, S

Nature 2014
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