JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3

Stable Identifier
Reaction [omitted]
Homo sapiens
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Interleukin 35 (IL35) binding activates the IL35 receptor complex and may presumably facilitate Tyrosine protein kinase JAK (JAK) phosphorylation. Subsequently, Signal transducer and activator of transcription 1 alpha/beta (STAT1) and Signal transducer and activator of transcription 3 alpha/beta (STAT3) may bind to the receptor complex and are activated by tyrosine phosphorylation. Although it is known that JAKs are involved in STATs phosphorylation (Stark GR and Darnell JE, 2012), it is not clear how other components of the IL35 receptor complex contribute to STAT1/STAT3 phosphorylation. For this reason, this event is assigned a black box status.
Literature References
PubMed ID Title Journal Year
24572363 IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Kaufmann, SH, Grützkau, A, Grün, JR, Lampropoulou, V, Li, R, Boudinot, P, Ries, S, Wirtz, S, Bar-Or, A, Shen, P, Meinl, E, Roch, T, McPherson, RC, Anderton, SM, Jaimes, Y, Hoehlig, K, Jouneau, L, Dörner, T, Leech, MD, Horn, K, Kühl, AA, Daridon, C, Sakwa, I, O'Connor, RA, Dang, VD, Stervbo, U, Neurath, M, Wilantri, S, Hilgenberg, E, Miyazaki, Y, Fillatreau, S

Nature 2014
24743305 Interleukin-35 induces regulatory B cells that suppress autoimmune disease

Kim, SH, Wingfield, PT, Mahdi, RM, Dambuza, IM, Yu, CR, Wang, RX, Sergeev, YV, Egwuagu, CE, Dolinska, MB

Nat. Med. 2014
Orthologous Events
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