JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated

Stable Identifier
R-HSA-8984012
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Interleukin 35 (IL35) presumably signal via a complex that includes Interleukin 27 receptor subunit alpha (Il27RA), Interleukin 12 receptor subunit beta 2 (IL12RB2) and the associated Tyrosine protein kinase JAK1 (JAK1) and JAK2 (Wang et al. 2014). Downstream, these JAKs are believed to phosphorylate Signal transducer and activator of transcription 1 (STAT1) and STAT3 (Stark GR and Darnell JE, 2012). As the series of events that induces JAK/STAT phosphorylation events in response to IL35 are not clear, this event is represented as a black box.

Literature References
PubMed ID Title Journal Year
24743305 Interleukin-35 induces regulatory B cells that suppress autoimmune disease

Wang, RX, Yu, CR, Dambuza, IM, Mahdi, RM, Dolinska, MB, Sergeev, YV, Wingfield, PT, Kim, SH, Egwuagu, CE

Nat. Med. 2014
24572363 IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Shen, P, Roch, T, Lampropoulou, V, O'Connor, RA, Stervbo, U, Hilgenberg, E, Ries, S, Dang, VD, Jaimes, Y, Daridon, C, Li, R, Jouneau, L, Boudinot, P, Wilantri, S, Sakwa, I, Miyazaki, Y, Leech, MD, McPherson, RC, Wirtz, S, Neurath, M, Hoehlig, K, Meinl, E, Grützkau, A, Grün, JR, Horn, K, Kühl, AA, Dörner, T, Bar-Or, A, Kaufmann, SH, Anderton, SM, Fillatreau, S

Nature 2014
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