Reactome | JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated

JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated

Stable Identifier

R-HSA-8984012

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated

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Interleukin 35 (IL35) presumably signal via a complex that includes Interleukin 27 receptor subunit alpha (Il27RA), Interleukin 12 receptor subunit beta 2 (IL12RB2) and the associated Tyrosine protein kinase JAK1 (JAK1) and JAK2 (Wang et al. 2014). Downstream, these JAKs are believed to phosphorylate Signal transducer and activator of transcription 1 (STAT1) and STAT3 (Stark GR and Darnell JE, 2012). As the series of events that induces JAK/STAT phosphorylation events in response to IL35 are not clear, this event is represented as a black box.

Literature References

PubMed ID	Title	Journal	Year
24572363	IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases Kaufmann, SH, Grützkau, A, Grün, JR, Lampropoulou, V, Li, R, Boudinot, P, Ries, S, Wirtz, S, Bar-Or, A, Shen, P, Meinl, E, Roch, T, McPherson, RC, Anderton, SM, Jaimes, Y, Hoehlig, K, Jouneau, L, Dörner, T, Leech, MD, Horn, K, Kühl, AA, Daridon, C, Sakwa, I, O'Connor, RA, Dang, VD, Stervbo, U, Neurath, M, Wilantri, S, Hilgenberg, E, Miyazaki, Y, Fillatreau, S	Nature	2014
24743305	Interleukin-35 induces regulatory B cells that suppress autoimmune disease Kim, SH, Wingfield, PT, Mahdi, RM, Dambuza, IM, Yu, CR, Wang, RX, Sergeev, YV, Egwuagu, CE, Dolinska, MB	Nat. Med.	2014