Reactome | JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated

JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated

Stable Identifier

R-HSA-8984012

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

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JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated

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Interleukin 35 (IL35) presumably signal via a complex that includes Interleukin 27 receptor subunit alpha (Il27RA), Interleukin 12 receptor subunit beta 2 (IL12RB2) and the associated Tyrosine protein kinase JAK1 (JAK1) and JAK2 (Wang et al. 2014). Downstream, these JAKs are believed to phosphorylate Signal transducer and activator of transcription 1 (STAT1) and STAT3 (Stark GR and Darnell JE, 2012). As the series of events that induces JAK/STAT phosphorylation events in response to IL35 are not clear, this event is represented as a black box.

Literature References

PubMed ID	Title	Journal	Year
24743305	Interleukin-35 induces regulatory B cells that suppress autoimmune disease Wang, RX, Yu, CR, Dambuza, IM, Mahdi, RM, Dolinska, MB, Sergeev, YV, Wingfield, PT, Kim, SH, Egwuagu, CE	Nat. Med.	2014
24572363	IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases Shen, P, Roch, T, Lampropoulou, V, O'Connor, RA, Stervbo, U, Hilgenberg, E, Ries, S, Dang, VD, Jaimes, Y, Daridon, C, Li, R, Jouneau, L, Boudinot, P, Wilantri, S, Sakwa, I, Miyazaki, Y, Leech, MD, McPherson, RC, Wirtz, S, Neurath, M, Hoehlig, K, Meinl, E, Grützkau, A, Grün, JR, Horn, K, Kühl, AA, Dörner, T, Bar-Or, A, Kaufmann, SH, Anderton, SM, Fillatreau, S	Nature	2014