IL35 binds IL27RA:IL12RB2 receptor

Stable Identifier
R-HSA-8984001
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Interleukin 35 (IL35) is a heteromeric complex of Interleukin 12 subunit alpha (IL12A) and Interleukin 27 subunit alpha (IL27). IL35 can trigger the activation of the Janus Kinase (JAK) bound heterodimeric receptor composed of Interleukin 27 receptor subunit alpha (Il27RA) and Interleukin 12 recetor subunit beta 2 (IL12RB2). JAKs are believed to be associated with the receptor before receptor activation (Behrmann et al., 2004). Consequently, IL12RB2:IL27RA facilitates the phosphorylation of STAT1:STAT3 heteromer downstream. Physiologically, this may result in the expansion of regulatory B cells and suppression of T and B cell proliferation. As it is not clear whether the dimeric receptor can form in the absence of ligand, formation of the receptor dimer is represented here as a black box event.

Literature References
PubMed ID Title Journal Year
24743305 Interleukin-35 induces regulatory B cells that suppress autoimmune disease

Wang, RX, Yu, CR, Dambuza, IM, Mahdi, RM, Dolinska, MB, Sergeev, YV, Wingfield, PT, Kim, SH, Egwuagu, CE

Nat. Med. 2014
24572363 IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Shen, P, Roch, T, Lampropoulou, V, O'Connor, RA, Stervbo, U, Hilgenberg, E, Ries, S, Dang, VD, Jaimes, Y, Daridon, C, Li, R, Jouneau, L, Boudinot, P, Wilantri, S, Sakwa, I, Miyazaki, Y, Leech, MD, McPherson, RC, Wirtz, S, Neurath, M, Hoehlig, K, Meinl, E, Grützkau, A, Grün, JR, Horn, K, Kühl, AA, Dörner, T, Bar-Or, A, Kaufmann, SH, Anderton, SM, Fillatreau, S

Nature 2014
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