Reactome | IL35 binds IL27RA:IL12RB2 receptor

IL35 binds IL27RA:IL12RB2 receptor

Stable Identifier

R-HSA-8984001

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region, cytosol

ReviewStatus

5/5

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Interleukin 35 (IL35) is a heteromeric complex of Interleukin 12 subunit alpha (IL12A) and Interleukin 27 subunit alpha (IL27). IL35 can trigger the activation of the Janus Kinase (JAK) bound heterodimeric receptor composed of Interleukin 27 receptor subunit alpha (Il27RA) and Interleukin 12 recetor subunit beta 2 (IL12RB2). JAKs are believed to be associated with the receptor before receptor activation (Behrmann et al., 2004). Consequently, IL12RB2:IL27RA facilitates the phosphorylation of STAT1:STAT3 heteromer downstream. Physiologically, this may result in the expansion of regulatory B cells and suppression of T and B cell proliferation. As it is not clear whether the dimeric receptor can form in the absence of ligand, formation of the receptor dimer is represented here as a black box event.

Literature References

PubMed ID	Title	Journal	Year
24572363	IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases Kaufmann, SH, Grützkau, A, Grün, JR, Lampropoulou, V, Li, R, Boudinot, P, Ries, S, Wirtz, S, Bar-Or, A, Shen, P, Meinl, E, Roch, T, McPherson, RC, Anderton, SM, Jaimes, Y, Hoehlig, K, Jouneau, L, Dörner, T, Leech, MD, Horn, K, Kühl, AA, Daridon, C, Sakwa, I, O'Connor, RA, Dang, VD, Stervbo, U, Neurath, M, Wilantri, S, Hilgenberg, E, Miyazaki, Y, Fillatreau, S	Nature	2014
24743305	Interleukin-35 induces regulatory B cells that suppress autoimmune disease Kim, SH, Wingfield, PT, Mahdi, RM, Dambuza, IM, Yu, CR, Wang, RX, Sergeev, YV, Egwuagu, CE, Dolinska, MB	Nat. Med.	2014