Reactome | STAT1 and STAT4 associate with IL12RB2:IL6ST receptor

STAT1 and STAT4 associate with IL12RB2:IL6ST receptor

Stable Identifier

R-HSA-8983996

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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STAT1 and STAT4 associate with IL12RB2:IL6ST receptor

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Interleukin-35 (IL35) binding activates the IL35 receptor complex and facilitates JAKs phosphorylation. Subsequently, Signal transducer and activator of transcription 1-alpha/beta (STAT1) and STAT4 bind to the receptor complex and are activated by tyrosine phosphorylation (Collison et al. 2012). This is a black box event because the receptor subunit responsible for STAT4 binding to the receptor is unclear. However, it is reported that simultaneous activation of IL12RB2 or IL6ST homodimer receptors do not promote the formation of pSTAT1:pSTAT4 and only the activation of the IL12RB2:IL6ST heteromeric receptor favours pSTAT1:pSTAT4 formation. For this reason, STAT1 and STAT4 are simultaneously considered in the binding, activation and release events.

Literature References

PubMed ID	Title	Journal	Year
22306691	The composition and signaling of the IL-35 receptor are unconventional Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM	Nat. Immunol.	2012