Interleukin-35 (IL35) can signal via IL35 receptors triggering the JAK/STAT pathway downstream. Signal transducer and activator of transcription 4-alpha/beta (STAT4) binds to the JAK associated-IL35 receptor complex and are activated via phosphorylations. Subsequently, phosphorylated p-STAT4 dissociates from the receptor complex (Collison et al. 2012). This is a black box event because there is no literature evidence about the exact mechanism of the release of STAT4 from the receptor complex.
Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM
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