STAT4 binds IL12RB2:IL12RB2

Stable Identifier
R-HSA-8983876
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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STAT4 binds IL12RB2:IL12RB2
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Interleukin-35 (IL35) binding activates the IL35 receptor complex and facilitates JAKs phosphorylation. Subsequently, Signal transducer and activator of transcription 4-alpha/beta (STAT4) binds to the receptor complex and is activated by tyrosine phosphorylation (Collison et al. 2012). This is a black box event because the receptor subunit responsible for STAT4 binding to the receptor is unclear.

Literature References
PubMed ID Title Journal Year
22306691 The composition and signaling of the IL-35 receptor are unconventional

Collison, LW, Delgoffe, GM, Guy, CS, Vignali, KM, Chaturvedi, V, Fairweather, D, Satoskar, AR, Garcia, KC, Hunter, CA, Drake, CG, Murray, PJ, Vignali, DA

Nat. Immunol. 2012
Participants
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Output
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hasEvent
Orthologous Events
STAT4 binds IL12RB2:IL12RB2 (Mus musculus)
Authored
Varusai, TM  (2016-12-15)
Reviewed
Singh, K  (2017-07-05)
Pylayeva-Gupta, Y  (2017-08-09)
Created
Varusai, TM  (2017-03-30)