Interleukin-35 (IL35) binding activates the IL35 receptor complex and facilitates JAKs phosphorylation. Subsequently, Signal transducer and activator of transcription 4-alpha/beta (STAT4) binds to the receptor complex and is activated by tyrosine phosphorylation (Collison et al. 2012). This is a black box event because the receptor subunit responsible for STAT4 binding to the receptor is unclear.
Collison, LW, Delgoffe, GM, Guy, CS, Vignali, KM, Chaturvedi, V, Fairweather, D, Satoskar, AR, Garcia, KC, Hunter, CA, Drake, CG, Murray, PJ, Vignali, DA
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