Reactome | JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4

JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4

Stable Identifier

R-HSA-8983872

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4

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Interleukin 35 (IL35) binding activates the IL35 receptor complex and may facilitate Tyrosine protein kinase JAK (JAK) phosphorylation. Subsequently, Signal transducer and activator of transcription 4 alpha/beta (STAT4) may bind to the receptor complex and is activated by tyrosine phosphorylation (Collison et al. 2012). JAK2 is known to be involved in the phosphorylation of STAT1 (Higashi T et al., 2005).

Literature References

PubMed ID	Title	Journal	Year
16324152	Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I Mizobe, T, Higashi, T, Morimoto, H, Tanaka, Y, Minami, Y, Yoshida, Y, Tsukada, J, Mouri, F	Genes Cells	2005
22306691	The composition and signaling of the IL-35 receptor are unconventional Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM	Nat. Immunol.	2012