JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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Interleukin 35 (IL35) binding activates the IL35 receptor complex and may facilitate Tyrosine protein kinase JAK (JAK) phosphorylation. Subsequently, Signal transducer and activator of transcription 4 alpha/beta (STAT4) may bind to the receptor complex and is activated by tyrosine phosphorylation (Collison et al. 2012). JAK2 is known to be involved in the phosphorylation of STAT1 (Higashi T et al., 2005).

Literature References
PubMed ID Title Journal Year
16324152 Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I

Mizobe, T, Higashi, T, Morimoto, H, Tanaka, Y, Minami, Y, Yoshida, Y, Tsukada, J, Mouri, F

Genes Cells 2005
22306691 The composition and signaling of the IL-35 receptor are unconventional

Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM

Nat. Immunol. 2012
Catalyst Activity

protein tyrosine kinase activity of IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane]

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