Interleukin 35 (IL35) binding activates the IL35 receptor complex and may facilitate Tyrosine protein kinase JAK (JAK) phosphorylation. Subsequently, Signal transducer and activator of transcription 4 alpha/beta (STAT4) may bind to the receptor complex and is activated by tyrosine phosphorylation (Collison et al. 2012). JAK2 is known to be involved in the phosphorylation of STAT1 (Higashi T et al., 2005).
Mizobe, T, Higashi, T, Morimoto, H, Tanaka, Y, Minami, Y, Yoshida, Y, Tsukada, J, Mouri, F
Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM
protein tyrosine kinase activity of IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane]
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