JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated

Stable Identifier
R-HSA-8983870
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Interleukin 35 (IL35) may presumably signal via a complex that includes Tyrosine protein kinase JAK2 (JAK2) associated with Interleukin 12 receptor beta 2 (IL12RB2) dimers (Collison et al. 2012). JAKs are believed to phosphorylate Signal transducers and activator of transcription (STATs) (Stark GR and Darnell JE, 2012). As the series of events that induce JAK/STAT phosphorylation events in response to IL35 are not clear, this event is represented as a black box.

Literature References
PubMed ID Title Journal Year
22306691 The composition and signaling of the IL-35 receptor are unconventional

Collison, LW, Delgoffe, GM, Guy, CS, Vignali, KM, Chaturvedi, V, Fairweather, D, Satoskar, AR, Garcia, KC, Hunter, CA, Drake, CG, Murray, PJ, Vignali, DA

Nat. Immunol. 2012
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