IL35 binds IL12RB2:IL12RB2 receptor

Stable Identifier
Reaction [omitted]
Homo sapiens
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Interleukin 35 (IL35) is a heteromeric complex conformed by Interleukin 12 subunit alpha (IL12A) and Interleukin 27 subunit alpha (IL27). IL35 may presumably stimulate Janus Kinase (JAK) bound homodimers of Interleukin 12 receptor beta 2 (IL12RB2). JAKs are believed to be associated with the receptor before receptor activation (Behrmann et al., 2004). Subsequently, this triggers the phosphorylation of STAT4 downstream. The physiological consequence of this signalling is the suppression of T cell response. The event is represented as a black box due to the incomplete knowledge about the ligand binding to monomers followed by dimerization or binding directly to the dimers.

Literature References
PubMed ID Title Journal Year
12829785 Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

Chow, DC, Boulanger, MJ, Garcia, KC, Brevnova, EE

Science 2003
22306691 The composition and signaling of the IL-35 receptor are unconventional

Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM

Nat. Immunol. 2012
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