Inferred from mouse: GRB2 associated binding protein 2 (GAB2) is phosphorylated in response to Interleukin-2 (IL2) and Interleukin-15 (IL15) stimulation. Its phosphorylation is greatly diminished by mutation of the Y338 site in Interleukin-2 Receptor beta chain (IL2RB, IL2Rβ) that recruits SHC transforming protein 1 (SHC1) (Gadina et al. 2000, Wöhrle et al. 2009, Gesbert et al. 1998, Brockdorff et al. 2001). The core Interleukin-15 (IL15) receptor complex consists of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15Rα), Interleukin-2 receptor beta subunit (IL2RB, IL2Rβ), which is associated with JAK1 and Interleukin-2 receptor gamma subunit (IL2RG, IL2Rγ), which is associated with JAK3 (Johnston et al. 1995). In this event, the IL15 receptor complex also includes phosphorylated SHC1, GRB2 and GAB2. This is a black box event because the kinase responsible for GAB2 phosphorylation has not been demonstrated.
transmembrane receptor protein tyrosine kinase activity of IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane]
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