IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2

Stable Identifier
R-HSA-8983424
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Synonyms
GAB2 is activated
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IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2
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Inferred from mouse: GRB2 associated binding protein 2 (GAB2) is phosphorylated in response to Interleukin-2 (IL2) and Interleukin-15 (IL15) stimulation. Its phosphorylation is greatly diminished by mutation of the Y338 site in Interleukin-2 Receptor beta chain (IL2RB, IL2Rβ) that recruits SHC transforming protein 1 (SHC1) (Gadina et al. 2000, Wöhrle et al. 2009, Gesbert et al. 1998, Brockdorff et al. 2001). The core Interleukin-15 (IL15) receptor complex consists of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15Rα), Interleukin-2 receptor beta subunit (IL2RB, IL2Rβ), which is associated with JAK1 and Interleukin-2 receptor gamma subunit (IL2RG, IL2Rγ), which is associated with JAK3 (Johnston et al. 1995). In this event, the IL15 receptor complex also includes phosphorylated SHC1, GRB2 and GAB2. This is a black box event because the kinase responsible for GAB2 phosphorylation has not been demonstrated.

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane]
Physical Entity
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane]
Activity
transmembrane receptor protein tyrosine kinase activity (0004714)
Inferred From
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2:Gab2 phosphorylates Gab2 (Mus musculus)
Authored
Duenas, C  (2017-08-07)
Reviewed
Patidar, M  (2017-08-07)
Created
Duenas, C  (2017-03-23)