IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2

Stable Identifier
R-HSA-8983384
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
GRB2 binds SOS
ReviewStatus
5/5
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IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2
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Son of sevenless homolog 2 (SOS2) is believed to bind the Interleukin-15 (IL15) receptor complex (Mishra et al. 2014). This is inferred from the binding of GRB2 to Interleukin-2 receptor beta subunit (IL2RB, IL2Rβ) in the IL15 receptor complex (Zambricki et al. 2005) and Interleukin-2 receptor complex (Zhu et al. 1994) and from events that follow SHC-GRB2 association in IL2 receptor signaling. The Interleukin-15 (IL15) receptor complex consists mainly of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15Rα), Interleukin-2 receptor beta subunit (IL2RB, IL2Rβ), which is associated with JAK1 and Interleukin receptor gamma subunit, which is associated with JAK3 (Johnston et al. 1995). In IL2 signaling, the resulting GRB2:SOS complex activates the Ras-Raf pathway (Zhu et al. 1994) and is believed to participate in similar events in IL15 signaling (Anduyah et al. 1997, Mishra et al. 2014). This is a black box event because SOS1 binding to GRB2 in response to IL15 has not been demonstrated.
Literature References
PubMed ID Title Journal Year
16212621 Signaling T-cell survival and death by IL-2 and IL-15

Sprent, J, Burakoff, S, Carpenter, C, Kishimoto, H, Milford, E, Shigeoka, A, Zambricki, E, McKay, D

Am. J. Transplant. 2005
9126349 Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15

Cooper, RS, Adunyah, SE, Wheeler, BJ

Biochem. Biophys. Res. Commun. 1997
24737791 Molecular pathways: interleukin-15 signaling in health and in cancer

Mishra, A, Caligiuri, MA, Sullivan, L

Clin. Cancer Res. 2014
Participants
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Output
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Orthologous Events
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Canis familiaris)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Gallus gallus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Mus musculus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Rattus norvegicus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Sus scrofa)
Authored
Duenas, C  (2017-08-07)
Reviewed
Patidar, M  (2017-08-07)
Created
Duenas, C  (2017-03-23)
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