Reactome | IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2

IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2

Stable Identifier

R-HSA-8983384

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Synonyms

GRB2 binds SOS

Locations in the PathwayBrowser

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Summation

Son of sevenless homolog 2 (SOS2) is believed to bind the Interleukin-15 (IL15) receptor complex (Mishra et al. 2014). This is inferred from the binding of GRB2 to Interleukin-2 receptor beta subunit (IL2RB, IL2R?) in the IL15 receptor complex (Zambricki et al. 2005) and Interleukin-2 receptor complex (Zhu et al. 1994) and from events that follow SHC-GRB2 association in IL2 receptor signaling. The Interleukin-15 (IL15) receptor complex consists mainly of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15R?), Interleukin-2 receptor beta subunit (IL2RB, IL2R?), which is associated with JAK1 and Interleukin receptor gamma subunit, which is associated with JAK3 (Johnston et al. 1995). In IL2 signaling, the resulting GRB2:SOS complex activates the Ras-Raf pathway (Zhu et al. 1994) and is believed to participate in similar events in IL15 signaling (Anduyah et al. 1997, Mishra et al. 2014). This is a black box event because SOS1 binding to GRB2 in response to IL15 has not been demonstrated.

Literature References

PubMed ID	Title	Journal	Year
9126349	Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15 Adunyah, SE, Wheeler, BJ, Cooper, RS	Biochem. Biophys. Res. Commun.	1997
16212621	Signaling T-cell survival and death by IL-2 and IL-15 Zambricki, E, Shigeoka, A, Kishimoto, H, Sprent, J, Burakoff, S, Carpenter, C, Milford, E, McKay, D	Am. J. Transplant.	2005
24737791	Molecular pathways: interleukin-15 signaling in health and in cancer Mishra, A, Sullivan, L, Caligiuri, MA	Clin. Cancer Res.	2014