Signal transducer and activator of transcription 3 (STAT3) and Signal transducer and activator of transcription 5A/5B (STAT5A and STAT5B respectively or STAT5) dimers translocate from the cytosol to the nucleoplasm. 10 ng/mL Interleukin-15 (IL15) induces the nuclear localization of phosphorylated STAT3, unless inhibited by neutralizing anti-IL15 or anti-Interleukin receptor alpha subunit (IL15RA, IL15Rα) mAbs (Giron Michel et al.2003, Johnston et al. 1995).This is a black box event because nuclear translocation of phosphorylated STAT3:STAT5 dimers has not been demonstrated but is inferred from other Jak-Stat signaling events.
van Dijk, M, Clay, D, Fogli, M, Chouaib, S, Bompais, H, Lebousse-Kerdilès, C, Briard, D, Ferrini, S, Azzarone, B, Meazza, R, Péault, B, Caignard, A, Brouty-Boyé, D, Giron-Michel, J
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